Alcohol kills brain cells / Absinthe & Hemingway’s Aunt Roberta / Neuro-Biology

I prepared this summary for facilitating your understanding of this topic 🙂

Ethanol is present in alcoholic beverages as a consequence of the fermentation of carbohydrates with yeast. Alcohols are organic molecules assembled from carbon (C), oxygen (O), and hydrogen (H) atoms. When 2 carbons are present, the alcohol is called ethanol (also known as ethyl alcohol).

So, when we drink alcohol most of the ethanol we incorporate in our body is broken down in the liver by an enzyme called alcohol dehydrogenase (ADH), which transforms ethanol into a toxic compound called acetaldehyde (CH3CHO), a known carcinogen.

In addition to the toxicity of ethanol, the main psychoactive component of alcoholic beverages, other physiological symptoms may arise from the activity of acetaldehyde, a metabolite of alcohol.

Acetaldehyde is the first product generated during the metabolism of alcohol (chemically known as ethanol). It is generated primarily in the liver by the enzyme alcohol dehydrogenase (ADH). The acetaldehyde then is converted rapidly to acetate by the enzyme aldehyde dehydrogenase (ALDH).

Spirits have the highest concentration of alcohol and most contain around 40% ABV. Strength can vary considerably, however. Some vodkas contain 30% ethanol, while some bourbons may be around 60% ABV and certain ‘high proof’ spirits can have up to 95% alcohol content.

*TIP: Whiskey contains more alcohol than vodka which has an average alcohol content of about 35% (vodka has 37-40% of alcohol). Whiskey (40-60% of alcohol) is made of grains (barley, rye, and corn). Whereas vodka is made by potatoes or grains. Whiskey contains more sugar before it ferments.

*TIP: Black tea stimulates the enzyme that breaks down acetaldehyde, while green tea promotes the breakdown of alcohol. Drink water. Drinking water may reduce the rate or how much alcohol is ingested, while carbonated water may encourage the breakdown of acetaldehyde.

* Spirits

Spirits are distilled alcoholic beverages. Some of the more popular examples of spirits include tequila, rum, gin, vodka, whiskey, and bourbon. It’s hard to pinpoint the exact origin of distilled liquors, but scholars’ best guess puts the first distillation around the thirteenth century. In most cases, spirits are liquor and liquors are alcohol. Wine, beer, and cider are all examples of alcohol, but they are not spirits.

While Hemingway suggests drinking “three to five of these slowly”, we would definitely have to disagree. And last on our list, but certainly not the least (amount of alcohol, that is), we have the Aunt Roberta. This cocktail contains 100% liquor and is widely regarded as THE strongest cocktail in the world.

How do you make an Aunt Roberta cocktail?

1 part of Blackberry liquor, 2 parts of Absinthe, 1.5 parts of Gin, 3 parts of Vodka, and 1 part of Brandy are fused and shaken in a cocktail shaker, filled with ice. The mixture is strained and poured into a glass for a smooth consistency. Voila!

What is absinthe in the Bible?

Absinthe’s popularity grew steadily through the 1840s, when it was given to French troops as a malaria preventive, and the troops brought home their taste for it. Absinthe became so popular in bars, bistros, cafés, and cabarets by the 1860s that the hour of 5 pm was called l’heure verte (“the green hour”).

In the New Testament: Apsinthos is believed to refer to a plant of the genus Artemisia, used metaphorically to mean something with a bitter taste. The English rendering “wormwood” refers to the dark green oil produced by the plant, which was used to kill intestinal worms.

It is spirit with a high alcohol content traditionally produced from wormwood, anise, and other herbs such as fennel. These herbs give absinthe its hallmark green colour. Wormwood contains thujone, which has been identified as the agent rumoured to cause hallucinations and convulsions when consumed in high doses.

24 Aug 2022

Dr. Andrew Huberman discusses the impact of alcohol on the brain.

Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab Podcast.

What is The Pomodoro Technique?

  1. Identify a task or tasks that you need to complete.
  2. Set a timer for 25 minutes.
  3. Work on a task with no distractions.
  4. When the alarm sounds, take a 5-minute break.
  5. Repeat the process 3 more times.
  6. Take a longer 30-minute break and start again.

Get 5 Free Travel Packs, Free Liquid Vitamin D and more from AG1 at https://drinkag1.com/wisdom (discount automatically applied)

Chris and Andrew Huberman discuss how bad alcohol really is for you. Just how bad is alcohol for your health according to Andrew Huberman?

What does Andrew Huberman prefer to consume rather than drink alcohol? What are the long-term effects of drinking alcohol according to Andrew Huberman?

5 tips for Men to increase Testosterone / More Testosterone or more Estrogens are good for men ? / Neuro-Biology

All males are born females … and die as females… with more estrogens winning over testosterone!

While men and women both create Testosterone and Estrogen, the quantity varies. Testosterone in women is typically between 1/10th and 1/20th of the amount in men. Similarly, men produce a small fraction of the Estrogen women produce, with an average of around 10–40 pg/ml of Estradiol.

Estrogen is one of two sex hormones commonly associated with people assigned female at birth (AFAB), including cisgender women, transgender men and nonbinary people with vaginas. Along with progesterone, estrogen plays a key role in your reproductive health.

Testosterone is an androgen, which is a “male” sex hormone that plays a role in reproduction, growth, and maintenance of a healthy body. In men, testosterone is mainly produced in the testes.

Testosterone levels affect the skin much like estrogen. The higher your testosterone, the firmer and tighter your skin appears. In men, low testosterone (low-T) is associated with wrinkles, muscle loss and thinning hair.

Aromatase inhibitors decrease the levels of estradiol, which counteract the estradiol’s negative feedback mechanism at the pituitary gland level and consequently increase the levels of gonadotrophins, LH, and FSH, and result in a rise in serum testosterone.

Circulating testosterone activates the androgen receptor (AR) and is also converted into estrogen in the brain via aromatase. This conversion is the primary source of estrogen to the male brain. It is unclear whether testosterone and estrogen signaling interact to masculinize neural circuits.

During early development the gonads of the fetus remain undifferentiated; that is, all fetal genitalia are the same and are phenotypically female. After approximately 6 to 7 weeks of gestation, however, the expression of a gene on the Y chromosome induces changes that result in the development of the testes.

27 Dec 2022

Derek from More Plates More Dates breaks down how to increase your testosterone naturally. What does More Plates More Dates say are the most important tactics for testosterone boosting? How does sleep, diet and supplementation impact testosterone for men?

6 Jul 2022

Dr Andrew Huberman gives his thoughts on Derek from More Plates More Dates. Does Andrew Huberman think that Derek is a good addition to the world of information about health and fitness? Does Huberman Lab agree with Derek’s position on hormones?

@hubermanlab 1 year ago Thank you for hosting me Chris. I misspoke on Nolvadex— it’s not an aromatase inhibitor; apologies. Other aromatase inhibitors were described correctly.

22 Nov 2022

Be sure to check with your doctor before using the following medicines:

Tongkat Ali — https://amzn.to/3gAHQ9g

Fadogia Agrestis — https://amzn.to/3hU6ZvZ

Natural Ways to increase your testosterone ! / Hormones & Neuro-Biology

I prepared a summary to give you context and introduce you to this topic : )

Mouth breathing is often just a habit that was developed at an early age, a pattern that was unconsciously ingrained. Due to respiratory neuroplasticity we now know that we can retrain our breathing patterns, meaning any poor functioning of the respiratory system can be reversed through consistent effort.

Breathing through your mouth can actually be the cause of your cold or sickness. When we breathe through our mouths, the air that we breathe tends to be dry and cold air. This air can irritate our airways, making them more susceptible to infection. This could be why you wake up with a mild sore throat in the morning.

You may notice mouth breathers usually have a recessed or weak chin and little to no jawline. This is because the mouth gapes open all the time, which alters facial and jaw development as a child grows.

Nose breathing is more beneficial than mouth breathing. Breathing through your nose can help filter out dust and allergens, boost your oxygen uptake, and humidify the air you breathe in. Mouth breathing, on the other hand, can dry out your mouth.

Nose Breathing is sometimes called the art of breath control. Alternate-nostril breathing is one type of pranayama or breathing practice, also known as nadi shodhana. Alternate-nostril breathing doesn’t just belong to yoga, though.

The chronic shortness of breath and low oxygen levels characteristic of COPD (Chronic Obstructive Pulmonary Disease) usually contribute to fatigue, a resistance to exercise, and deterioration of muscle tissue. Increased fatigue, loss of lean muscle mass, and an early onset of frailty are common symptoms of low testosterone.

High testosterone during development is linked to facial features such as a chiselled jaw, broad face, narrow eyes and rugged cheekbones. But normal adult testosterone levels are not required for normal erections to occur and that when this threshold of testosterone is reached, additional amounts do not further increase the frequency, amplitude, or rigidity of erections. Contrary to common belief, it’s not the amount of testosterone or DHT that causes baldness; it’s the sensitivity of your hair follicles. That sensitivity is determined by genetics. The AR gene makes the receptor on hair follicles that interact with testosterone and DHT.

Zinc deficiency reduces testosterone levels and zinc supplementation improves testosterone levels. Some studies have shown that magnesium supplementation can increase testosterone levels in men. It is recommended that men have at least 400–420 mg per day of magnesium, which can come from food or a combination of food and supplements. Having too much or too little can be dangerous for your health. To provide a large amount of omega-3s in the body will benefit men on increasing testosterone levels in the body.

During a documented experiment, the men who received ashwagandha showed a greater increase in testosterone levels. Their testosterone levels increased by 96.2 nanograms per deciliter (ng/dL). Comparatively, the men in the placebo group experienced an increase of 18.0 ng/dL.

*TIP: apnea is a condition in which your breathing stops and restarts many times while you sleep. This can prevent your body from getting enough oxygen.

*TIP: Include foods rich in the natural testosterone boosters: zinc (oysters, beef, oats), magnesium (nuts, seeds, spinach, beans), and vitamin D (fatty fish, fortified milk).

*TIP: Although you might have heard that using tape to block mouth breathing can help your nose-breathing at many social media platforms, this is NOT true nor beneficial. Mouth taping not only doesn’t help you to breathe through your nose, it’s also highly dangerous. It can cause obstructed breathing and create other more serious sleep disorders like obstructive sleep apnea and sleep disruption.

1 Mar 2024

In this video, Andrew Huberman discusses the fastest natural way to increase testosterone levels and improve overall health — nasal breathing.

00:00 Intro
00:28 Apnea
02:52 Mouth Breathing
04:35 Sleep and Testosterone
07:48 Nasal Breathing

Andrew D. Huberman is an American neuroscientist and tenured associate professor in the department of neurobiology and psychiatry and behavioural sciences at Stanford University School of Medicine.

23 Oct 2023

Delve into the science behind naturally boosting testosterone levels. If you’re looking to optimize your hormonal balance and overall health, this is a must-watch!

Andrew D. Huberman is an American neuroscientist and tenured associate professor in the department of neurobiology and psychiatry and behavioural sciences at Stanford University School of Medicine.

00:24 – Benefits of Testosterone
03:03 – Sleep & Testosterone
04:08 – Light Exposure & Testosterone
05:14 – Weight Training & Testosterone
05:41 – Testosterone-Enhancing Supplements

Why do addictions happen? / Dopamine Ups & Downs, Cravings, Neurobiology & Neuroscience

I prepared a summary to introduce you to this topic:

The crucial brain reward neurotransmitter activated by addictive drugs is dopamine, specifically in the “second-stage” ventral tegmental area to nucleus accumbens link in the brain’s reward circuitry. This has been learned over many decades of research, and is based upon many congruent findings.

Animal studies have shown that when cortisol is released with chronic stress, changes in the brain’s response can lead to lower dopamine levels and increased cravings. Stress has also been associated with increased levels of the hormone ghrelin, again causing stronger cravings.

Today, Crystal meth releases more dopamine in the brain compared to any other drug. Dopamine is a brain neurotransmitter that serves a number of functions, including the feeling of pleasure. When crystal meth leads to a powerful surge of dopamine in the brain, people feel motivated to seek it out again and again.

Additionally, the intensified dopamine response in the brain that mood-altering drugs produce does not naturally stop once the behaviour is initiated or completed (as is the case with natural reward behaviours such as eating or having sex); as a result, cravings for the rewards associated with the drug continue to occur.

When we constantly overstimulate ourselves with things like excessive screen time, gaming, and unhealthy eating, it can lead to issues like addiction and poor mental health. During a dopamine detox, you have to avoid activities like social media, gaming, junk food, and even work.

Engage in Natural Dopamine-Boosting Activities: Physical exercise, meditation, exposure to sunlight, engaging in hobbies, and listening to music can naturally increase dopamine levels. These activities not only help in elevating mood but also in reducing cravings.

1 Nov 2023

Dr. Andrew Huberman discusses the science of addiction, focusing on the role of dopamine to understand why quick rewards make addiction so hard to combat. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.

2 Nov 2023

Dr. Andrew Huberman discusses the dopamine-driven cycle of craving and motivation.

*Seeking for more info & help? Visit https://www.uk-rehab.com/addiction/psychology/reward-system/

hypnosis & brain health | neuroscience, neuroplasticity & wellbeing

21 Feb 2022

My guest is Dr. David Spiegel MD, Associate Chair of Psychiatry & Behavioral Sciences, Director of the Center on Stress and Health and Director of the Center for Integrative Medicine at Stanford University School of Medicine.

Dr. Spiegel has more than 40 years of clinical and research experience with hypnosis, stress physiology, and psychotherapy. In this episode, we examine the role of clinical hypnosis for the treatment of trauma, chronic pain, anxiety and more.

Dr. Spiegel explains how to determine your level of ‘hypnotizability’ and provides case studies of incredible successes with hypnosis to treat a variety of ailments. We also discuss how breathing, vision and directed mental focus can modulate internal states and enhance performance.

Additionally, we discuss how the adoption of self-hypnosis techniques can reduce stress and enhance sleep in anyone. Dr. Spiegel teaches us how hypnosis works at the neural circuit level to enhance cognitive flexibility. Throughout the episode, Dr. Spiegel summarizes key clinical trials and peer-reviewed findings and resources to work with a trained clinical professional or to do guided self-hypnosis.

Dr. David Spiegel Links:
Stanford Center for Stress and Health: https://stresshealthcenter.stanford.edu
Support Dr. Spiegel’s Research at Stanford (tax-deductible): https://stan.md/3p36Yqd
Dr. Spiegel’s Published Work: https://stanford.io/3GYzL5C
Email: david@reveri.com

Article Links:
Posthypnotic Amnesia in Hypnotizability Assessment: Validation of a New Scoring System for the Hypnotic Induction Profile: https://bit.ly/3uYrlsC
Post-traumatic stress disorder and cancer: https://bit.ly/3h36vzX
Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability: https://bit.ly/33BvMyj
Hypnosis reduces distress and duration of an invasive medical procedure for children: https://bit.ly/3p3wOuf

Other Links:
Society for Clinical and Experimental Hypnosis: https://www.sceh.us
American Society for Clinical Hypnosis: https://bit.ly/3JHU88Y
Watch Andrew’s Hypnosis Session with Dr. Spiegel: https://youtu.be/tlTzVB6TGT0
Reveri website: https://www.reveri.com
Reveri app (iOS): https://apple.co/3sT5RL8
Join the Waitlist for Reveri for Android: https://bit.ly/3JB2wa0

Timestamps:
00:00:00 Dr. David Spiegel MD, Hypnosis
00:04:16 AG1 (Athletic Greens), Thesis, ROKA
00:09:09 Clinical Hypnosis
00:16:45 Stage Hypnosis
00:20:25 Neurobiology of Hypnosis
00:26:04 ADHD
00:28:22 Hypnosis for Stress & Sleep
00:32:12 Hypnosis to Strengthen Neural Connections
00:37:19 Restructuring Trauma Narratives
00:45:14 Ketamine Therapy
00:50:07 Self-directed Hypnosis, Reveri
00:56:53 Eliminating Obsessive Thoughts, Superstitions
01:01:50 ‘Hypnotizability’, the Spiegel Eye-roll Test
01:15:36 EMDR (Eye Movement Desensitization Reprocessing)
01:21:43 Confronting Stress & Trauma
01:27:56 The Mind-Body Connection
01:31:35 Dealing with Grief
01:35:45 Hypnosis in Children & Groups
01:40:06 Drug Therapies & Hypnosis
01:42:39 Breathing Patterns, Peak Performance
01:50:00 Zero-Cost Support, YouTube, Spotify & Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman’s teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

tools to enhance brain & body health | neuroscience, neurobiology & wellbeing

12 Jul 2021

In this episode I discuss science-supported tools for enhancing focus, learning, creativity, sleep, physical strength and endurance and brain and body health. I explain each protocol in detail, the rationale behind it, and how the protocol can be adjusted depending on individual needs. I set these tools in the context of a 24-hour day as a way of framing how one might incorporate these tools and protocols into their own daily routine.

Timestamps:
00:00:00 Introduction: Protocols for sleep, mood, focus, exercise creativity
00:04:08 Sponsors
00:08:50 Protocol 1: Record Your Daily Waking Time & Temperature Minimum
00:12:07 Protocol 2: Self-Generate Forward Motion (Outdoors)
00:17:00 Protocol 3: View Natural Light For 10-30min Every Morning
00:22:43 What To Do If You Can’t View The Sun: Blue Light
00:26:50 Protocol 4: Hydrate Correctly
00:28:00 Protocol 5: Delay Caffeine 90-120m After Waking
00:30:48 Protocol 6: Fast (or Fat-Fast) Until Noon
00:32:30 What Actually Breaks A Fast & What Doesn’t?
00:34:30 Fat Loss & Glucagon-Like Peptide 1 (GLP1), Yerba Mate, Guayusa Tea
00:37:30 Protocol 7: Optimize Deep Work: Visual Elevation, Ultradian Cycles, White Noise
00:48:30 Optimal Time of Day To Do Hard Mental Work
00:52:07 Protocol 8: Optimal Exercise; 3:2 Ratio
01:03:54 Tools for Training & Mental Focus: Fasting, Salt, Stimulants, Alpha-GPC
01:10:00 Protocol 9: Eat For Brain Function & Mood
01:17:39 Protocol 10: Get Your Testosterone & Estrogen In An Ideal Range
01:24:00 Protocol 11: Reset the Mind & Body, Enhance Neuroplasticity, Reveri.com
01:31:15 Protocol 12: Hydrate Correctly, Nap Rules
01:33:29 Protocol 13: View Late Afternoon/Evening Light To Support Sleep & Dopamine
01:39:00 Protocol 14: Eat Dinner That Promotes Serotonin, Calm Sleep
01:44:27 Protocol 15: Optimize Falling & Staying Asleep; Tools & Supplements That Work
01:55:00 Protocol 16: Preventing Middle of the Night Waking
01:59:10 Protocol 17: Weekends, Recovering From A Poor Nights Sleep
02:05:20 Neural Network, Supplement Sources, Sponsors

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman’s teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

positive thinking to reduce stress, trauma & anxiety | neuroscience

19 Feb 2021

Andrew Huberman is a neuroscientist at Stanford University who runs the Huberman Lab, which studies how the brain functions, how it changes through experiences, and how to repair the brain after injury or disease. In his career, Andrew has made many important contributions to the fields of brain development, brain plasticity, and neural regeneration, and repair.

He’s received numerous awards and recognitions for his research and publications, including the McKnight Foundation Neuroscience Scholar Award, the Biomedical Scholar Award from the Pew Charitable Trusts, and the Cogan Award for Research in Vision and Ophthalmology.

In addition to being a tenured professor of neurobiology and ophthalmology at Stanford University, Dr. Andrew is a brilliant neuroscientist and teacher — he excellently explains complicated concepts in a way that everyday people can understand them and use neuroscience to improve their lives!

Andrew’s goal is to understand how the brain allows us to sense, evaluate, and respond to the world around us. He’s actively working on methods to re-wire and repair eye-to-brain connections for people who suffer from blinding diseases, as well as investigating emotions and how they drive human behavior.

Dr. Andrew is clearly an expert on how the human brain works — I can’t wait for him to share his wisdom with you today!