2023’s breakthroughs in: Microbiomes, Mithocondria & Biology, Consciousness: Neuroscience & Psychology

I prepared a summary to introduce you to this topic:

Models of consciousness aim to inspire new experimental protocols and aid interpretation of empirical evidence to reveal the structure of conscious experience. Nevertheless, no current model is univocally accepted on either theoretical or empirical grounds.

The four current and major neuroscientific theories of conscious experience are: global neuronal workspace (GNW) theory, re-entrant processing theory, predictive coding, and integrated information theory (IIT).

A fantasy is an idea with no basis in reality and is basically your imagination unrestricted by reality. Reality is the state of things as they exist. It’s what you see, hear, and experience.

Imagery and perception are the same? A large body of evidence has shown that imagery and perception can behave in strikingly similar ways. For most of us, both can produce the subjective feeling (or qualia) of ‘seeing’; however, imagery is often a weaker and fuzzier version of visual perception.

The Perky Effect describes the relationship between real visual information (perception) and mental imagery. Discovered by C. W. Perky in 1910, her experiments were able to show that visualization of images can depress the sensitivity of perception of real visual targets.

What did Perky find about projecting a faint image of a banana while participants created a mental image of a banana? Their descriptions of the mental image matched the real image.

*Definition & Explanation of the Perky Effect https://plato.stanford.edu/archIves/sum2020/entries/mental-imagery/perky-experiment.html

19 Dec 2023

Quanta Magazine’s coverage of biology in 2023, including important research progress into the nature of consciousness, the origins of our microbiomes and the timekeeping mechanisms that govern our lives and development. Read about more breakthroughs from 2023 at Quanta Magazine: https://www.quantamagazine.org/the-bi…

00:05 The Research of Consciousness: Our minds are constantly taking in new external information while also creating their own internal imagery and narratives. How do we distinguish reality from fantasy? This year, researchers discovered that the brain has a “reality threshold” against which it constantly evaluates processed signals. – Original story with links to research papers can be found here: https://www.quantamagazine.org/is-it-…

04:30 Microbiomes Evolve With Us: This year, scientists provided clear evidence that the organisms in our microbiome —the collection of bacteria and other cells that live in our guts and elsewhere on our body — spread between people, especially those with whom we spend the most time. This raises the intriguing possibility that some illnesses that aren’t usually considered communicable might be. — Original story with links to research papers can be found here: https://www.quantamagazine.org/global…

08:43 How Life Keeps Time: The rate at which an embryo develops and the timing of when its tissues mature vary dramatically between species. What controls the ticking of this developmental clock that determines an animal’s final form? This year, a series of careful experiments suggest that mitochondria may very well serve dual roles as both the timekeeper and power source for complex cells. – Original story with links to research papers can be found here: https://www.quantamagazine.org/what-m…

fisetin & quercetin, the revolution of flavonoids | science, epigenetics & longevity

March 2022

Dr David Sinclair explain what is senolytics, especially quercetin and fisetin, other than reducing senescent cells, both has another amazing benefit behind them.

https://pubmed.ncbi.nlm.nih.gov/12939… Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan 2003 paper https://pubmed.ncbi.nlm.nih.gov/29988… Senolytics improve physical function and increase lifespan in old age

Dec 2021

Not all polyphenols are water soluble, during digestion, they are largely destroyed by gastric acid. And are excreted in the urine shortly after entering the body. Fat-soluble polyphenols are fat-shielded, and they can survive through the small intestine and blood stream.

Eventually, they are absorbed into the fatty outer layer of our cells to offer protection from oxidative stress and free radical damage. According to Dr David Sinclair, the presence of fat is key to the absorption of Resveratrol, Curcumin, Quercetin and Fisetin.

Feb 2022

00:43 quercetin & fisetin

Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss Rapamycin, Fisetin, Quercetin and Longevity Rapalogs.

The Sinclair Lab website: https://sinclair.hms.harvard.edu/ Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6 Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b NAD and cancer in mice: https://go.nature.com/32xl1wp Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q Fisetin enhances longevity in mice: https://bit.ly/3o10hom Quercetin and fatty liver disease: https://bit.ly/3H4KWdF Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3 Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

yamanaka factor: cambiar 4 genes de una célula para reprogramar las células y rejuvenecer | ciencia, epigenética & longevidad

Los factores de Yamanaka consisten en modificar 4 genes a las células adultas para reprogramarlas.

Estas son: Oct 4, Klf4, Sox2 y c-Myc .

El envejecimiento de nuestras células es controlado por cuatro genes principales, llamados factores de Yamanaka, podemos revertir el envejecimiento de nuestras células modificando su expresión genética, algo que dará lugar, en un futuro cercano, a un aumento de expectativa de vida muy importante.

*David Sinclair (from harvard medical school laboratory) recover a lost eye nerve in mice.

more info at:

cellular reprogramming to restore your vision | ERA (Epigenetic Reprogramming of Aging) & science

sirtuins, stem cells, longevity & reverse aging | epigenetics & covid19

NMN will help promote your DNA repair ! | cellular rejuvenation science

magnesium for your brain ! | science, health & wellbeing

anti aging NMN + TMG | health & wellbeing

how mRNA technology in covid vaccines can help get vaccines for cancer & HIV sooner | science & health

genetic material: messenger mRNA vaccines: moderna & pfizer-bioNtech,

9 Apr 2021

The mRNA technology at the heart of two Covid-19 shots has been decades in the making. Now it may soon be used to fight cancer and HIV.

the theory of parallel universe explained easily for beginners | science

multiple universes & parallel universes theories

23rd July 2019

The theory of multiple or parallel universes is one that blurs the line between scientific reality and science fiction. It’s a pretty huge topic of debate in the scientific community, with big names on both sides.

If you believe that multiple universes exist, then maybe you can feel a little better about having the great genius physicist Stephen Hawking in your camp!

He had a pretty spectacular theory on multiple universes. This is the idea that everything you thought you ever knew – our planet, the solar system, our galaxy, all the other stars and galaxies out there as far as our fancy telescopes can see – it’s just one itsy bitsy piece of a really giant puzzle!

TIMESTAMPS: What a “multiverse” really is 1:26

There are infinite me’s and you’s each in their own universe 😱 2:25

What these universes look like 3:17

What would a parallel version of our world look like? 4:45

How to prove that? 5:32

How could you possibly travel to a different universe? 8:24

Dr Bruce Aylward head of the WHO (world health organization) returned from china | science & health

Coronavirus outbreak: Canadian WHO doctor returns from China with critical COVID-19 lessons

5th march 2020

Dr. Bruce Aylward, the Canadian head of the World Health Organization’s COVID-19 mission in China, has just returned from Wuhan. Global National’s Dawna Friesen asks him about what lessons can be learned from the outbreak there, and why he believes worst-case scenario planning for countries like Canada is essential.

why china … 2002 coronavirus … 2003 SARS …? | diseases & coronavirus | how china treats animals is crucial

china does not respect the planet nor the animals and this gives place to epidemics

And why COVID-19 was bound to happen. 

NOTE: As our expert Peter Li points out in the video, “The majority of the people in China do not eat wildlife animals. Those people who consume these wildlife animals are the rich and the powerful –a small minority.”

This video explains how the people of China are themselves victims of the conditions that led to coronavirus. The virus is affecting many different countries and cultures, and there is never justification for xenophobia or racism.

You can find further reading on this on Vox: https://www.vox.com/2020/2/7/21126758… https://www.vox.com/policy-and-politi… https://www.vox.com/identities/2020/3…

As of early March 2020, a new coronavirus, called COVID-19, is in more than 70 countries and has killed more than 3,100 people, the vast majority in China. That’s where the virus emerged back in December 2019.

This isn’t a new phenomenon for China; in 2003, the SARS virus also emerged there, and under similar circumstances, before spreading around the world and killing nearly 800. Both SARS and COVID-19 are in the “coronavirus” family, and both appear to have emerged from animals in China’s notorious wildlife markets.

Experts had long predicted that these markets, known to be potential sources of disease, would enable another outbreak. The markets, and the wildlife trade that supports them, are the underlying problem of these pandemics; until China solves that problem, more are likely to emerge.

how can covid-19 can affect you ? | science & health

HOW DOES COVID-19 AFFECT THE BODY?

Coronaviruses (CoV) are a family of viruses that cause sicknesses like the common cold, as well as more severe diseases, such as Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome.

A novel coronavirus (nCoV) is a new strain – one that hasn’t previously been recognized in humans. Coronaviruses cause diseases in mammals and birds. A zoonotic virus is one that is transmitted between animals and people.

When a virus circulating in animal populations infects people, this is termed a “spillover event”. How does CoVID-19 affect the body?

The virus is fitted with protein spikes sticking out of the envelope that forms the surface and houses a core of genetic material. Any virus that enters your body looks for cells with compatible receptors – ones that allow it to invade the cell.

Once they find the right cell, they enter and use the cell’s replication machinery to create copies of themselves. It is likely that COVID-19 uses the same receptor as SARS – found in both lungs and small intestines. It is thought that CoVID-19 shares many similarities with SARS, which has three phases of attack: viral replication, hyper-reactivity of the immune system, and finally pulmonary destruction. Early on in infection, the coronavirus invades two types of cells in the lungs – mucus and cilia cells.

Mucus keeps your lungs from drying out and protects them from pathogens. Cilia beat the mucus towards the exterior of your body, clearing debris – including viruses! – out of your lungs. Cilia cells were the preferred hosts of SARS-CoV, and are likely the preferred hosts of the new coronavirus.

When these cells die, they slough off into your airways, filling them with debris and fluid. Symptoms include a fever, cough, and breathing difficulties. Many of those infected get pneumonia in both their lungs. Enter the immune system. Immune cells recognize the virus and flood into the lungs.

The lung tissue becomes inflamed. During normal immune function, the inflammatory process is highly regulated and is confined to infected areas. However, sometimes the immune system overreacts, and this results in damage to healthy tissue. More cells die and slough off into the lungs, further clogging them and worsening the pneumonia.

As damage to the lungs increases, stage three begins, potentially resulting in respiratory failure. Patients that reach this stage of infection can incur permanent lung damage or even die. We see the same lesions in the lungs of those infected by the novel coronavirus as those with SARS. SARS creates holes in the lungs, so they look honeycomb-like.

This is probably due to the aforementioned over-reactive immune response, which affects tissue both infected and healthy and creates scars that stiffen the lungs. As such, some patients may require ventilators to aid breathing. The inflammation also results in more permeable alveoli. This is the location of the thin interface of gas exchange, where your lungs replace carbon dioxide in your blood with fresh oxygen you just inhaled. Increased permeability causes fluid to leak into the lungs.

This decreases the lungs’ ability to oxygenate blood, and in severe cases, floods them so that you become unable to breathe. Sometimes, this can be fatal. The immune system’s over-reaction can also cause another kind of damage. Proteins called cytokines are the immune system’s alarm system, recruiting immune cells to the infection site. Over-production of cytokines can result in a cytokine storm, where there is large-scale inflammation in the body.

Blood vessels become more permeable and fluid seeps out. This makes it difficult for blood and oxygen to reach the rest of the body and can result in multi-organ failure. This has happened in the most severe cases of CoVid-19. Although there are no specific treatments for coronaviruses, symptoms can be treated through supportive care. Also, vaccines are currently in development.

What can you do to protect yourself from CoVid-19? Basic protocol comes down to regular hand washing, avoiding close contact with anyone coughing or sneezing, avoiding unnecessary contact with animals, washing hands after contact with animals, thoroughly cooking meat and eggs prior to consumption, and covering your mouth and nose while coughing or sneezing.

Respiratory viruses are typically transmitted via droplets in sneezes or coughs of those infected, so preventing their travel stops the spread of disease.

Is the blue light from our mobile phones making us older ? | tech & health

It’s not just the sun we have to worry about. Turns out, the cellphones we’re all carrying could be giving us wrinkles. Nathan Rousseau Smith has the story.

Supplements to balance your serotonin production, muscle mass, your sleep and more !

5-HTP  is Griffonia Simplicifolia Bean Extract.

¿Cómo funciona el HTP?

El cuerpo produce 5-HTP de forma natural a partir de triptófano y, a continuación, lo convierte en serotonina.

Este neurotransmisor tiene muchos poderosos efectos sobre el cerebro ayudando a mejorar el estado de animo y, por lo tanto, la salud en general.

Los médicos sugieren tomar un suplemento de 5-HTP en lugar de un suplemento de serotonina porque puede tener acceso al cerebro desde el torrente sanguíneo, mientras que la serotonina no puede.

* Mejora los patrones de sueno

* Estabiliza los cambios de humor

* Ayuda a una dieta sana para aquellas personas que comen por ansiedad

* Mejora los niveles de Serotonina

BCAA 

¿Cúales son y para que sirven?.
Los aminoácidos ramificados son tres aminoácidos esenciales (leucina, isoleucina y valina), los cuales desempeñan importantes funciones fisiológicas:
1) Estimulan la síntesis de proteínas musculares y disminuyen su degradación después del ejercicio.
2) Durante el ejercicio, pueden actuar como sustratos energéticos necesarios para la contracción muscular.
3) Disminuyen la fatiga durante el ejercicio prolongado, a través de efectos indirectos sobre el sistema nervioso central.
4) Estimulan parcialmente la producción de insulina, que ayuda a transportar glucosa y aminoácidos al interior de las células. 

BRENDA’S SKINNY GUT | or PROBIOTICS MORE THAN 20 BILLION AND VARIOUS STRAINS

• All Dr Mercola Complete Probiotics bottles are sold with the “Dr Mercola Premium Products” seal of authenticity on the cap of the bottle

• 70 BILLION CFU! Dr Mercola packs 70 Billion “gut friendly” bacteria in each serving of Complete Probiotics – Providing you with extremely effective digestive benefits

SPIRULINA

• ★WHAT IT IS: Spirulina is an amazing vegetarian whole superfood that has the ability to increase energy and detox your body. Should be created by sunshine and nature are in their raw form and not an subjected to machines to form an extract.