We will live longer so reverse ageing to live better ! / Epigenetics

April 13, 2024 / brain perks by mvm

22 Mar 2024

Is ageing a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.

Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?

We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world’s oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?

Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.

3 fruits to include in your diet / Longevity, Age Reversing Food & Habits

April 3, 2024 / brain perks by mvm

Reduce inflammation, cellular damage and oxidative stress

Antioxidants reducing the risk of free radicals

Reduce blood sugar and Weight management

27 Mar 2024

Introducing Doctor David Sinclair, a distinguished Professor of Genetics at Harvard Medical School renowned for his expertise in longevity. With a focus on holistic health practices, he advocates for a lifestyle that includes predominantly plant-based nutrition, intermittent fasting, and select supplements to promote longevity and vitality.

Our “Healthy Long Life” channel offers an in-depth exploration of his invaluable insights, but today, we’re delving into the top three fruits he incorporates into his diet. This focus is particularly noteworthy as Dr. Sinclair emphasizes the detrimental effects of excessive sugar intake on our overall health and aging process. While he generally prioritizes vegetables over fruits due to their lower fructose content, there are three fruits that hold a special place in his regimen.

Join us as we uncover the three fruits endorsed by Dr. Sinclair for their contributions to a healthy, prolonged life.

0:00 Start
0:40 Sugar is Bad!
0:57 Cancer Cells love Sugar
1:33 Top Fruit that Dr. David Sinclair Eats
5:24 Second Fruit that Dr. David Sinclair Eats
6:49 Third Fruit that Dr. David Sinclair Eats

►Disclaimer: Healthy Long Life does not provide medical advice and the information provided throughout our videos, including but not limited to, text, graphics, images, and other materials, are entirely intended for informational purposes. The content of Healthy Long Life’s videos is not intended to replace the professional medical advice that you should seek from your doctor. All the information presented in these videos is for educational purposes only.

►Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for ‘fair use’ for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS.

The benefits of Alpha Lipoic Acid, a powerful antioxidant just second to glutathione / Health & Epigenetics

February 7, 2024 / brain perks by mvm

13 Jan 2024

Alpha Lipoic Acid | NAD+, Blood Sugar, and AGING Benefits!

28 Sept 2021

The health benefits of alpha lipoic acid for nerve repair, diabetes, heart health and more. [Subtitles] Alpha lipoic acid is a powerful antioxidant which is both fat soluble and water soluble. This means that it can travel through cells, and pass the blood brain barrier to help heal the human body and nervous system.

In today’s video we will be exploring the 10 key health benefits of alpha lipoic acid. You will also learn about which foods contain this antioxidant, and how you can take this as a supplement as a home remedy/therapy.

Note: The ALA we are talking about here is Alpha Lipoic Acid, not Alpha-Linolenic Acid which is a type of Omega-3. Don’t get these confused.

21 Jun 2020

18 Jul 2020

Benefits of alpha-lipoic acid:

1. Powerful antioxidant When you’re exposed to various things, you get free-radicals that can damage your DNA, cellular membranes, and mitochondria. Alpha-lipoic acid could help protect you from that.

2. Glucose sensitizer Alpha-lipoic acid could help normalize glucose levels.

3. Insulin sensitizer Alpha-lipoic acid could help normalize insulin levels.

4. Increases glutathione Glutathione is a powerful antioxidant that your body can make in the liver. It’s known as the master antioxidant.

5. Inhibits cancer It may inhibit certain types of cancer.

6. Helps with autonomic neuropathy This is a very common yet under-diagnosed condition related to diabetes. A good remedy may be to not only get on keto and intermittent fasting but to also start taking 600-1800mg of alpha-lipoic acid.

7. Protects cell membranes Alpha-lipoic acid mainly deals with the protection of lipids. This is why it could help protect your cell membranes. If there’s damage to the membrane, all sorts of issues could happen.

8. Could help with diabetic retinopathy High levels of sugar can damage the retinas. Alpha-lipoic acid may help minimize the damage to the retinas. Doing keto and intermittent fasting may also be beneficial. If you’re going to take alpha-lipoic acid as a supplement, you may want to take it on an empty stomach. If you have a major condition you’re trying to deal with, the supplement form may be the most beneficial. You can also get alpha-lipoic acid from: • Organ meats • Spinach • Broccoli • Brussels sprouts • Tomatoes

latest news on epigenetics and clock reprogramming | the methylation clock

August 11, 2022 / brain perks by mvm

May 5, 2022

fisetin & quercetin, the revolution of flavonoids | science, epigenetics & longevity

July 22, 2022July 30, 2022 / brain perks by mvm

March 2022

Dr David Sinclair explain what is senolytics, especially quercetin and fisetin, other than reducing senescent cells, both has another amazing benefit behind them.

https://pubmed.ncbi.nlm.nih.gov/12939… Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan 2003 paper https://pubmed.ncbi.nlm.nih.gov/29988… Senolytics improve physical function and increase lifespan in old age

Dec 2021

Not all polyphenols are water soluble, during digestion, they are largely destroyed by gastric acid. And are excreted in the urine shortly after entering the body. Fat-soluble polyphenols are fat-shielded, and they can survive through the small intestine and blood stream.

Eventually, they are absorbed into the fatty outer layer of our cells to offer protection from oxidative stress and free radical damage. According to Dr David Sinclair, the presence of fat is key to the absorption of Resveratrol, Curcumin, Quercetin and Fisetin.

Feb 2022

00:43 quercetin & fisetin

Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss Rapamycin, Fisetin, Quercetin and Longevity Rapalogs.

The Sinclair Lab website: https://sinclair.hms.harvard.edu/ Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6 Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b NAD and cancer in mice: https://go.nature.com/32xl1wp Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q Fisetin enhances longevity in mice: https://bit.ly/3o10hom Quercetin and fatty liver disease: https://bit.ly/3H4KWdF Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3 Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

why is fasting beneficial? | genes & sirtuins, epigenome & epigenetics

July 19, 2022July 19, 2022 / brain perks by mvm

July 2022

Dr. David Sinclair explains how skipping meals (fasting) can actually reverse the aging process. He explains the results of some studies done on how timed eating and fasting can lead to a healthier, more younger, you.

June 2022

Caution: If you have an existing health condition or are taking medication, always consult your healthcare practitioner before going for prolonged periods without eating.

David Sinclair, Harvard professor and author of Lifespan: Why We Age – And Why We Don’t Have To, is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects.

how to reverse the hallmarks of aging | epigenetics, sirtuins & DNA methylation

July 19, 2022 / brain perks by mvm

May 2022

Dr David Sinclair talks about the potential effects on NMN on different gender and our hormone levels in this clip.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSincla….

DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.

NMN’s safety and trial tests | cancer, extended lifespan & epigenetics

July 19, 2022 / brain perks by mvm

May 2022

Dr David Sinclair explains about is there any risk of taking NMN in this short clip.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSincla….

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss NAD Intravenous Drips, THE Bioavailability of NAD Boosters and the risks of cancer.

Links:
The Sinclair Lab website: https://sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b
NAD and cancer in mice: https://go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: https://bit.ly/3o10hom
Quercetin and fatty liver disease: https://bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt
Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.
The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

improve your mitochondrial health | epigenetics to reverse aging

June 21, 2022 / brain perks by mvm

27 May 2022

Dr David Sinclair lists 5 supplements that can boost our mitochondrial function in this clip. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.

He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSincla….

NMN supplement new trial results | epigenetics, DNA & mitochondria repair

June 21, 2022 / brain perks by mvm

3 May 2022

The NMN human studies are flying in thick and fast, and I’m pleased to share this one with you that in my opinion is good quality and doesn’t try to overinterpret their results.