We will live longer so reverse ageing to live better ! / Epigenetics

April 13, 2024 / brain perks by mvm

22 Mar 2024

Is ageing a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.

Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?

We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world’s oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?

Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.

Stopping aging ? No, let’s reverse aging | Epigenetics & DNA methylation clocks

May 26, 2023 / brain perks by mvm

14 Mar 2023

First hint that body’s ‘biological age’ can be reversed. The Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial was the first human trial shows reversal of biological age. In this video, the authors of the paper, Dr. Greg fahy and Dr Steve Horvath review the trial, present some new evidence, and express their thoughts on it.

TRIIM is the first case demonstrating the potential for reversibility of aging. It also demonstrates the value of DNA methylation clocks as serving as a measure of age and a call for change when the biological age accelerates. These preliminary data are based on only nine participants and require a more in-depth study on a large number of people. Nevertheless, this discovery could potentially revolutionize the field of aging and open the window of opportunity for reversing aging.

latest news on epigenetics and clock reprogramming | the methylation clock

August 11, 2022 / brain perks by mvm

May 5, 2022

the epigenetics of cancer & a new promising drug: DOSTARLIMAB | how to turn on and off our genes to battle cancer

August 11, 2022 / brain perks by mvm

Jun 7, 2022

Treatment with the immunotherapy dostarlimab showed promising results in a small trial of more than a dozen rectal cancer patients, according to new research, but further study is needed and it is too early to call it a cure. CNN’s Erin Burnett speaks to Dr. Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center.

May 16, 2021

It’s not about the code, it’s how you use it—this physician scientist investigates how cancer uses our own DNA against us. #MedallistMonday is for sharing the stories of award-winning scientists who are changing the world.

Subscribe to see more. Professor Mark Dawson studies how cancer cells exploit parts of our DNA that are usually silenced to create new treatments.

His research in epigenetics has resulted in several novel cancer therapies which he has taken from laboratory through to clinical application. He received the 2021 Jacques Miller Medal for his contributions to experimental biomedicine.

Jun 8, 2022

In a medical trial, patients with advanced rectal cancer have all gone into remission after taking the same drug, and scientists are hoping Dostarlimab is just the tip of the iceberg.

meditation, neuroscience & epigenetics: a combo to improve your life quality

August 11, 2022 / brain perks by mvm

Apr 19, 2022

This week, I’m welcoming back a bonafide EXPERT on how our BRAINS FUNCTION for another engaging exchange. DR. JOE DISPENZA has traveled to more than 33 countries to give lectures on discovering the full potential of the human brain and has three New York Times bestselling books to his name.

He has devoted much of his life to studying neuroscience and neuroplasticity, quantitative electroencephalogram (QEEG) measurements, epigenetics, mind-body medicine, and brain/heart coherence.

Don’t let those words intimidate you. It all boils down to Dr. Dispenza digging into the INNER WORKINGS OF WHAT GOES ON INSIDE YOUR HEAD.

Do you want to know how STRESS affects the relationship between your HEART AND BRAIN?

Or why you cling on to the SUFFERING in your life instead of EXPLORING THE UNKNOWN?

Are you curious how athletes gain a MENTAL EDGE to compete at the highest levels?

What are the benefits to having all parts of your brain on the same “wavelengths” so that BRAIN COHERENCE works in your favor?

Dr. Dispenza has powerful INSIGHTS to help you shed unwanted thoughts and mental roadblocks using proven science-based research. You will discover how to replace what’s holding you back with CLARITY, INTENTIONAL CONSCIOUSNESS, and POSITIVE EMOTIONS.

This isn’t an hour spent talking about theories. It’s an hour of DOWNLOADABLE AND TEACHABLE STRATEGIES that will fortify how you think so you can change your life for the better.

Get ready because Dr. Joe is about to “DISPENZA” a lot of practical advice…

…and give your brain a lot of important things to think about.

0:00 Intro
1:41 What Joe is working & excited about
5:24 How stress causes the heart and brain to be incoherent
8:40 Moving from Beta, Alpha, Theta, to Gamma state
14:29 Clinging onto suffering rather than the unknown
16:01 Demystifying the present moment & rewiring your brain
22:30 What happens when you have a coherent heart & brain
25:23 What is heart coherence?
27:33 Athletes having a mental edge
29:13 Creating from field instead of matter
35:11 Turning your adversities into wisdom
39:52 You don’t really want material things, you want the emotion they bring
42:05 Brain and heart coherence is teachable
46:57 What Dr Joe Dispenza would recommend to people wanting to change their life

fisetin & quercetin, the revolution of flavonoids | science, epigenetics & longevity

July 22, 2022July 30, 2022 / brain perks by mvm

March 2022

Dr David Sinclair explain what is senolytics, especially quercetin and fisetin, other than reducing senescent cells, both has another amazing benefit behind them.

https://pubmed.ncbi.nlm.nih.gov/12939… Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan 2003 paper https://pubmed.ncbi.nlm.nih.gov/29988… Senolytics improve physical function and increase lifespan in old age

Dec 2021

Not all polyphenols are water soluble, during digestion, they are largely destroyed by gastric acid. And are excreted in the urine shortly after entering the body. Fat-soluble polyphenols are fat-shielded, and they can survive through the small intestine and blood stream.

Eventually, they are absorbed into the fatty outer layer of our cells to offer protection from oxidative stress and free radical damage. According to Dr David Sinclair, the presence of fat is key to the absorption of Resveratrol, Curcumin, Quercetin and Fisetin.

Feb 2022

00:43 quercetin & fisetin

Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss Rapamycin, Fisetin, Quercetin and Longevity Rapalogs.

The Sinclair Lab website: https://sinclair.hms.harvard.edu/ Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6 Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b NAD and cancer in mice: https://go.nature.com/32xl1wp Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q Fisetin enhances longevity in mice: https://bit.ly/3o10hom Quercetin and fatty liver disease: https://bit.ly/3H4KWdF Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3 Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

why is fasting beneficial? | genes & sirtuins, epigenome & epigenetics

July 19, 2022July 19, 2022 / brain perks by mvm

July 2022

Dr. David Sinclair explains how skipping meals (fasting) can actually reverse the aging process. He explains the results of some studies done on how timed eating and fasting can lead to a healthier, more younger, you.

June 2022

Caution: If you have an existing health condition or are taking medication, always consult your healthcare practitioner before going for prolonged periods without eating.

David Sinclair, Harvard professor and author of Lifespan: Why We Age – And Why We Don’t Have To, is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects.

how to reverse the hallmarks of aging | epigenetics, sirtuins & DNA methylation

July 19, 2022 / brain perks by mvm

May 2022

Dr David Sinclair talks about the potential effects on NMN on different gender and our hormone levels in this clip.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSincla….

DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.

NMN’s safety and trial tests | cancer, extended lifespan & epigenetics

July 19, 2022 / brain perks by mvm

May 2022

Dr David Sinclair explains about is there any risk of taking NMN in this short clip.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSincla….

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss NAD Intravenous Drips, THE Bioavailability of NAD Boosters and the risks of cancer.

Links:
The Sinclair Lab website: https://sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b
NAD and cancer in mice: https://go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: https://bit.ly/3o10hom
Quercetin and fatty liver disease: https://bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt
Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.
The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

epigenetics: the anti-aging medicine | aging is just a medical condition that can be treated

June 21, 2022 / brain perks by mvm

15 Mar 2022

NOTE FROM TED: Research around aging discussed in this talk remains an ongoing field of study. Please do not look to this talk for health advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/t…

Have you ever wondered how long you will live? And if so, how could you change that number to live drastically longer? The science might be in your favor: follow David Sinclair, Australian biologist and professor of genetics at Harvard University, as he shares his research on slowing and reversing the process of aging in mice, and how the same technology may someday be transferable to humans.

David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine. David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx