brain training perks with neuroscience & neurolingistics cutting-edge knowledge, experience and trends will improve and boost your brain health and all your learning | education | lingüistics | english as a second language | ESL | ELT | second language acquisition | learning & teaching | neuroscience | neurology | holistic methodologies | management | effective communication | liaising with clients | travelling & tourism | general news | animal protectionism | youtube curator
Is ageing a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.
What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.
Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?
We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world’s oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?
Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.
NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.
New detection tools powered by AI have lifted the lid on what some are calling an epidemic of fraud in medical research and publishing. Last year, the number of papers retracted by research journals topped 10,000 for the first time.
One case involved the chief of a cancer surgery division at Columbia University’s medical centre. An investigation found that dozens of his cancer treatment studies contained dubious data and recycled images. Other scandals have hit Harvard on the East Coast and on the West Coast it is Stanford University. A scandal there resulted in the resignation of the president last year.
Chapters: 0:00 What we think we know about medical research 1:32 Arthur Caplan, NYU Langone Medical Center
don’t propose anything ! so they cannot say you did not fulfill your promises !
don’t explain anything ! people may understand and get angry!
say they are lying or talk about your kids ! distract and entertain your audience !
28 Jul 2015
Un video muestra al actual diputado por el PRO, Federico Sturzenegger, contando risueñamente los consejos que Durán Barba le dio en el marco de un debate. Honestidad brutal e insólitas recomendaciones. “Tenía que ir a un debate el año pasado (el video es de 2014) con otras dos personas.
The full conference is in the video below.
Y era uno de mis primeros debates, así que tuve una reunión de coaching con nuestro asesor político que es Jaime Durán Barba”, así comienza la exposicion del diputado Sturzenegger. (Luis Bruschtein/ Política). Emitido por Visión 7, noticiero de la TV Pública argentina, el martes 28 de julio de 2015.
The Challenges of Policymaking in Argentina
Wednesday, April 16, 2014
Federico Sturzenegger, Member of the Chamber of Representatives for the National Congress in Argentina will address: How does an academic make the transition from his office to public office, deal with the pressure of interest groups, approach consensus building in Congress? This talk will provide personal insights on how to make this transition and the lessons learned in the process, with the current economic and political situation of Argentina as background.
Federico Sturzenegger is currently a member of the Chamber of Representatives, National Congress, Argentina and Professor at Universidad Torcuato Di Tella. He holds a Ph.D. in Economics from MIT (1991), was Assistant Professor of Economics at UCLA (1991-1995), Chief Economist of YPF (1995-1998), Dean of the Business School at Di Tella (1998-2000/2002-2005), Secretary of Economic Policy of Argentina (2001), and Visiting Professor of Public Policy at the Kennedy School of Government, Harvard University (2005-2007) and President of Banco Ciudad (2008-2013). He has written or edited eight books, and has published extensively in the area of international finance and macroeconomics. Has been named a Young Global Leader by the World Economic Forum in 2005 and has received a Konex award for his contributions to economic theory in 2006.
The event is sponsored by the Program in Economic Policy Management and the Center on Global Economic Governance.
Dr David Sinclair lists 5 supplements that can boost our mitochondrial function in this clip. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.
He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
NOTE FROM TED: Research around aging discussed in this talk remains an ongoing field of study. Please do not look to this talk for health advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/t…
Have you ever wondered how long you will live? And if so, how could you change that number to live drastically longer? The science might be in your favor: follow David Sinclair, Australian biologist and professor of genetics at Harvard University, as he shares his research on slowing and reversing the process of aging in mice, and how the same technology may someday be transferable to humans.
David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine. David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
Dr David Sinclair expresses his view on exercise pattern and frequency. He emphasizes the important of moderation, rest and recycle, excess exercises may accelerate aging.
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.
He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
___________________________________________
DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
In late 2020, researchers, including Dr. David Sinclair, published a study that showed they could restore lost vision to old mice and mice with damaged retinal nerves, using partial cellular reprogramming, or PCR. To reduce cancer risk, they opted to try PCR, leaving out one of the Yamanaka factors. Dr. Yuancheng Lu, a study author, was looking for a safer way to rejuvenate aged cells, as there was concern that using c-Myc could cause cancer under certain circumstances. In the end, they opted to use only Oct4, Sox2, and Klf4 (OSK).
The good news was that even OSK alone was able to rejuvenate the damaged eye nerves in mice and restore vision. It also worked to improve age-related vision impairment in treated mice, and in mice that experienced increased eye pressure, an emulation of glaucoma. Study co-author, Dr. Sinclair, said in an article in Nature, “We set out with a question: If epigenetic changes are a driver of ageing, can you reset the epigenome?” In other words, “Can you reverse the clock?” The answer to that appears to be a resounding yes. In January, 2021 researchers showed that PCR rejuvenates human cells by about 30 years, making old, worn-out cells function like the cells of a person of 25.
They used an approach that exposed cells to enough reprogramming factors to push them beyond the limit at which they were considered somatic rather than stem cells – but only just beyond. The fibroblasts that were reprogrammed in this way retained enough of their epigenetic cellular memories to return to being fibroblasts once again. The team used a doxycycline-activated lentiviral package to expose the cells to the OSKM factors, as previous animal studies had done. According to the 2013 Horvath multi-tissue clock, after 13 days of PCR, sample cells that were nearly 60 years old became epigenetically equivalent to cells that were approximately 25 years old. The 2018 Horvath skin and blood clock showed that cells that were approximately 40 years old were also epigenetically returned to a 25-year-old state. It seems that reprogrammed cells revert to an epigenetic age of about 25, suggesting this is a peak of cellular prime, or the optimal functional age for cells.
The biggest hurdle to translating PCR to humans is to find a way to activate the Yamanaka factors in our cells without having to engineer our bodies to react to a drug such as doxycycline. This may require us to develop drugs capable of activating OSKM, editing every cell in our body to respond to a particular compound like doxycycline, which would be extremely challenging, though plausible. Another possibility is editing the germline so that children are born with a modification to respond to a chosen compound, an idea that currently is both technically challenging and an ethical nightmare. Whatever the solution, it needs to be practical.
Another major hurdle is to find a durable treatment, one that does not require constant upkeep. In mice, signs of aging returned rapidly when treatment stopped. Humans are not mice; we have superior repair systems and different metabolism. Still, it is likely that aging would return if treatment ended. The challenge is to find a cost-effective way to sustain treatment, perhaps using drugs, or transient gene therapy. If we can overcome these challenges, PCR could hold great promise for preventing, or even curing, diseases of aging.
One might envision an early, first-pass, preventative use of this approach in the young. Older people could receive PCR to halt or significantly slow their aging, reducing their risk of developing age-related diseases. Used in a more focused, refined manner, PCR could repair a certain organ or tissue damaged by injury or disease. In another scenario, gradual whole-body rejuvenation of older people might completely prevent age-related diseases and keep people healthy, active and vibrant, enjoying a longer life. Well-funded companies such as Altos Labs and Alphabet’s Calico are also investigating ways to achieve PCR without using Yamanaka factors. This new research direction may prove more practical, and safer. The rapid progress of medical technology could mean that PCR therapies may be available sooner than you think.
4 Oct 2020
Dr. Vittorio Sebastiano is an Assistant Professor at Stanford University. He has over 15 years of research experience in Developmental Biology, Nuclear Reprogramming, Stem Cell Biology and Regenerative Medicine. His lab has established a new technology named ERA (Epigenetic Reprogramming of Aging). ERA is based on the ideas of cellular reprogramming, with the goal to promote epigenetic rejuvenation of adult cells leaving their identity untouched.
This new technology has been patented and is being implemented by Turn Biotechnologies, of which Dr. Sebastiano is co-founder and Chair of the Scientific Advisory Board. The company is now developing partial cellular reprogramming techniques to reverse cellular aging.
A major cause of aging is thought to be the errors that accumulate in the epigenome, the system of proteins that packages the DNA and controls access to its genes. Dr. Vittorio Sebastiano and his colleagues are working on a way to reverse these errors and walk back the cells to their youthful state. And to show that this process does indeed restore the cells’ vigor and eliminate signs of aging.
NMN is the precursor of the molecule nicotinamide adenine dinucleotide (NAD+)
22 Oct 2021
NMN user reveals his experience in taking NMN 4 grams in an interview with Dr David Sinclair. Also he talks about his experience in taking Liposomal format as well. NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells NMN plays a key role in molecular pathways that keep our body running. NAD+ is the fuel that helps sirtuins sustain genome integrity and promote DNA repair.
Results from animal studies showed that raising NAD+ level in the body activates sirtuins and increases the lifespans of yeast, worms and mice. Although animal studies showed promising results in anti-aging properties, scientists are still studying how these results can translate to humans.
Dr David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
Oleic acid is a mono-unsaturated omega-9 fatty acid found in various animal and vegetable sources. For example, oleic acid is a component of olive oil and it’s in avocados and nuts as well. Also fasting will generate oleic acid out of our white adipose tissue, so oleic acid is a byproduct of fasting. According to Dr Sinclair, same as resveratrol, oleic acid is a potent activator of the longevity gene – Sirttuin 1.
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.
He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
brain-perks 