2023’s breakthroughs in: Microbiomes, Mithocondria & Biology, Consciousness: Neuroscience & Psychology

I prepared a summary to introduce you to this topic:

Models of consciousness aim to inspire new experimental protocols and aid interpretation of empirical evidence to reveal the structure of conscious experience. Nevertheless, no current model is univocally accepted on either theoretical or empirical grounds.

The four current and major neuroscientific theories of conscious experience are: global neuronal workspace (GNW) theory, re-entrant processing theory, predictive coding, and integrated information theory (IIT).

A fantasy is an idea with no basis in reality and is basically your imagination unrestricted by reality. Reality is the state of things as they exist. It’s what you see, hear, and experience.

Imagery and perception are the same? A large body of evidence has shown that imagery and perception can behave in strikingly similar ways. For most of us, both can produce the subjective feeling (or qualia) of ‘seeing’; however, imagery is often a weaker and fuzzier version of visual perception.

The Perky Effect describes the relationship between real visual information (perception) and mental imagery. Discovered by C. W. Perky in 1910, her experiments were able to show that visualization of images can depress the sensitivity of perception of real visual targets.

What did Perky find about projecting a faint image of a banana while participants created a mental image of a banana? Their descriptions of the mental image matched the real image.

*Definition & Explanation of the Perky Effect https://plato.stanford.edu/archIves/sum2020/entries/mental-imagery/perky-experiment.html

19 Dec 2023

Quanta Magazine’s coverage of biology in 2023, including important research progress into the nature of consciousness, the origins of our microbiomes and the timekeeping mechanisms that govern our lives and development. Read about more breakthroughs from 2023 at Quanta Magazine: https://www.quantamagazine.org/the-bi…

00:05 The Research of Consciousness: Our minds are constantly taking in new external information while also creating their own internal imagery and narratives. How do we distinguish reality from fantasy? This year, researchers discovered that the brain has a “reality threshold” against which it constantly evaluates processed signals. – Original story with links to research papers can be found here: https://www.quantamagazine.org/is-it-…

04:30 Microbiomes Evolve With Us: This year, scientists provided clear evidence that the organisms in our microbiome —the collection of bacteria and other cells that live in our guts and elsewhere on our body — spread between people, especially those with whom we spend the most time. This raises the intriguing possibility that some illnesses that aren’t usually considered communicable might be. — Original story with links to research papers can be found here: https://www.quantamagazine.org/global…

08:43 How Life Keeps Time: The rate at which an embryo develops and the timing of when its tissues mature vary dramatically between species. What controls the ticking of this developmental clock that determines an animal’s final form? This year, a series of careful experiments suggest that mitochondria may very well serve dual roles as both the timekeeper and power source for complex cells. – Original story with links to research papers can be found here: https://www.quantamagazine.org/what-m…

fisetin & quercetin, the revolution of flavonoids | science, epigenetics & longevity

March 2022

Dr David Sinclair explain what is senolytics, especially quercetin and fisetin, other than reducing senescent cells, both has another amazing benefit behind them.

https://pubmed.ncbi.nlm.nih.gov/12939… Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan 2003 paper https://pubmed.ncbi.nlm.nih.gov/29988… Senolytics improve physical function and increase lifespan in old age

Dec 2021

Not all polyphenols are water soluble, during digestion, they are largely destroyed by gastric acid. And are excreted in the urine shortly after entering the body. Fat-soluble polyphenols are fat-shielded, and they can survive through the small intestine and blood stream.

Eventually, they are absorbed into the fatty outer layer of our cells to offer protection from oxidative stress and free radical damage. According to Dr David Sinclair, the presence of fat is key to the absorption of Resveratrol, Curcumin, Quercetin and Fisetin.

Feb 2022

00:43 quercetin & fisetin

Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support

June 2022

In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss Rapamycin, Fisetin, Quercetin and Longevity Rapalogs.

The Sinclair Lab website: https://sinclair.hms.harvard.edu/ Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6 Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b NAD and cancer in mice: https://go.nature.com/32xl1wp Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q Fisetin enhances longevity in mice: https://bit.ly/3o10hom Quercetin and fatty liver disease: https://bit.ly/3H4KWdF Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3 Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.