We will live longer so reverse ageing to live better ! / Epigenetics

22 Mar 2024

Is ageing a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.

Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?

We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world’s oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?

Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.

Reversing your biological age / The Blueprint Project / Science, Tech & Epigenetics

10 Apr 2024

US tech entrepreneur Bryan Johnson took the internet by storm in 2021 when he began to work on reversing his biological age, spending millions in the process. He now says his goal is to ‘make death optional.’

Bryan walks us through what his daily routine includes to achieve these biohacking results. He reveals he takes 40 supplements a day, eats all of his meals before 11am, and uses laser treatment to help him turn back time.

22 Mar 2024

“We are losing when we create a lesser version of ourselves.” Bryan Johnson has created a blueprint to reverse-aging, and a vision for the future of humanity.

You might have seen Bryan Johnson on TikTok or in your Reels feed. He’s the man who spends $2 million every year to slow his speed of aging…and shares all of that information for free.

To slow down his aging, Johnson has tried some pretty extreme stuff like transfusions of his teenage son’s blood plasma (a practice he has since abandoned due to its ineffectiveness). He maintains a strict adherence to a meticulously calculated plant-based diet, and consumes over 100 supplements daily.

What propels this relentless pursuit of immortality? We found out while filming our Hard Reset episode, where we tested Bryan Johnson’s biohacking routine, and listened to him explain his philosophy for a healthier, longer future for humanity.

00:00 An algorithm for near-perfect health?
00:31 Who is Bryan Johnson?
02:10 What is the future of our existence?
03:04 What does the Blueprint protocol entail?
04:46 What does non-violence have to do with this lifestyle?
06:09 What does it mean to “be a zero?”
06:32 What is Bryan’s philosophy?
07:30 How does an ‘average’ person adopt this protocol?
08:51 What was Nick’s experience with the Blueprint protocol?
10:23 What does this mean for our future?

3 fruits to include in your diet / Longevity, Age Reversing Food & Habits

Reduce inflammation, cellular damage and oxidative stress

Antioxidants reducing the risk of free radicals

Reduce blood sugar and Weight management

27 Mar 2024

Introducing Doctor David Sinclair, a distinguished Professor of Genetics at Harvard Medical School renowned for his expertise in longevity. With a focus on holistic health practices, he advocates for a lifestyle that includes predominantly plant-based nutrition, intermittent fasting, and select supplements to promote longevity and vitality.

Our “Healthy Long Life” channel offers an in-depth exploration of his invaluable insights, but today, we’re delving into the top three fruits he incorporates into his diet. This focus is particularly noteworthy as Dr. Sinclair emphasizes the detrimental effects of excessive sugar intake on our overall health and aging process. While he generally prioritizes vegetables over fruits due to their lower fructose content, there are three fruits that hold a special place in his regimen.

Join us as we uncover the three fruits endorsed by Dr. Sinclair for their contributions to a healthy, prolonged life.

0:00 Start
0:40 Sugar is Bad!
0:57 Cancer Cells love Sugar
1:33 Top Fruit that Dr. David Sinclair Eats
5:24 Second Fruit that Dr. David Sinclair Eats
6:49 Third Fruit that Dr. David Sinclair Eats

►Disclaimer: Healthy Long Life does not provide medical advice and the information provided throughout our videos, including but not limited to, text, graphics, images, and other materials, are entirely intended for informational purposes. The content of Healthy Long Life’s videos is not intended to replace the professional medical advice that you should seek from your doctor. All the information presented in these videos is for educational purposes only.

►Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for ‘fair use’ for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS.

Replenish the levels of glutathione your DNA needs to stay healthy / Epigenetics, Health & Aging

8 Sept 2022

Glycine and NAC supplements “improve and reverse multiple age-associated abnormalities (including the decrease in glutathione which is the most important antioxidant in our body) to promote health in aging humans.

@calebveloz8666 My Doctor is a Professor of Neuroscience at a large University in America. He was impressed with this study, I suffer Long Covid from Delta last October. He put me on 1,800MG of NAC in split doses daily, and 3000-4000MG of Glycine to be taken with the NAC same time. Alot of my Back, Joint, Muscle pain is gone now. The Glycine he said at 3000-8000MG really calms the Brain, he was right, I can feel the calmness. Dr Stanfield Thank You for your tireless efforts to find ways to help the sick get well and the well stay well.

Anti aging Collagen diet supplementation | Health

21 May 2023

Surprisingly, the human studies consistently show that collagen supplements reverse the signs of skin aging.

25 Feb 2023

Here are the supplements that alongside a great diet, exercise, and sleep, actually improve our health

Stopping aging ? No, let’s reverse aging | Epigenetics & DNA methylation clocks

14 Mar 2023

First hint that body’s ‘biological age’ can be reversed. The Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial was the first human trial shows reversal of biological age. In this video, the authors of the paper, Dr. Greg fahy and Dr Steve Horvath review the trial, present some new evidence, and express their thoughts on it.

TRIIM is the first case demonstrating the potential for reversibility of aging. It also demonstrates the value of DNA methylation clocks as serving as a measure of age and a call for change when the biological age accelerates. These preliminary data are based on only nine participants and require a more in-depth study on a large number of people. Nevertheless, this discovery could potentially revolutionize the field of aging and open the window of opportunity for reversing aging.

why is fasting beneficial? | genes & sirtuins, epigenome & epigenetics

July 2022

Dr. David Sinclair explains how skipping meals (fasting) can actually reverse the aging process. He explains the results of some studies done on how timed eating and fasting can lead to a healthier, more younger, you.

June 2022

Caution: If you have an existing health condition or are taking medication, always consult your healthcare practitioner before going for prolonged periods without eating.

David Sinclair, Harvard professor and author of Lifespan: Why We Age – And Why We Don’t Have To, is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects.

expanding life expectancy and longevity | antiaging dubious drugs, NAD boosters & trends

28 May 2022

Can the aging process be reversed – or even halted, altogether? If we manage to decode this final mystery of our human biology, we might soon be able to eradicate age-related illnesses like cancer, dementia and heart problems. The race to invent the miracle pill is well underway. Today, international researchers are getting astonishingly close to realizing humanity’s dream of immortality.

The hunt for immortality gained traction with the discovery of Costa Rica’s so-called “Blue Zone,” by Luis Rosero-Bixby. In the “Blue Zone,” on the Nicoya Peninsular, he found a remarkable number of centenarians. Here, male life expectancy is the highest in the world. Their healthy lifestyle is one factor, but the promise of longevity is probably also because their telomeres – sections of DNA found at the end of chromosomes – are longer than those of the average person. It’s a field of research currently being explored by Maria Blasco in Madrid.

But this is just one of many possible factors influencing the process of aging. Senescent cells may also play a key role. Also known as “zombie cells”, these attack our body in old age and flood it with alarm signals until, at some point, we collapse under their weight. That’s a theory proposed by another researcher in Spain, Manuel Serrano. A billion-dollar industry is already knocking impatiently at the lab doors. The first to market the miracle pill is guaranteed incredible wealth.

That’s why investors are sponsoring young bio-startups in Hong Kong. Keen not be left out, US Big Tech is vying for the world’s best scientists. Alex Zhavoronkov has secured a slice of that pie, with a cash injection of more than 250 million dollars for his company’s work on aging research. Whereas some pioneers’ visions burst like bubbles, others rush to get other, rather more dubious products onto the market. But their efficacy is now measurable.

The epigenetic clock devised by Steve Horvath can measure our biological age, regardless of our actual age in years. With his research on the thymus gland, California’s Greg Fahy managed to not only decelerate the aging process, but reverse it. His initial study on humans showed that a particular drug cocktail took an average two-and-a-half years off their age.

Young biohackers like Nina Khera from Boston want everyone to benefit from this research. Together with friends, she’s working on the “epigenetic clock for all”. But while we’re busy trying to counter the aging process and all the illnesses it entails, fundamental questions arise: Should we be messing with nature like this? Are we about to overwhelm the planet with more and more people? Criminal biologist Mark Benecke in Cologne says that these questions are coming far too late.

aging is a disease | oleic acid (present in nuts & avocados) activates the longevity gene | DNA & the cell rejuvenating science

17 Nov 2021

Oleic acid is a mono-unsaturated omega-9 fatty acid found in various animal and vegetable sources. For example, oleic acid is a component of olive oil and it’s in avocados and nuts as well. Also fasting will generate oleic acid out of our white adipose tissue, so oleic acid is a byproduct of fasting. According to Dr Sinclair, same as resveratrol, oleic acid is a potent activator of the longevity gene – Sirttuin 1.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.

He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.

What is better for your brain … diet or exercise ?| The brain on food by Gary Wenk

What is most influential to your brain … food or exercise?

Gary L. Wenk, author of Your Brain on Food: How Chemicals Control Your Thoughts and Feelings, Second Edition, discusses the debate between diet and exercise.

Dr. Gary L. Wenk is a Professor of Psychology & Neuroscience & Molecular Virology, Immunology and Medical Genetics at Ohio State University. He has served on the faculty of Johns Hopkins University and the University of Arizona.

He was the Program Director for the Neurobiology of Learning and Memory & Biological Basis of Behavior Program at the National Science Foundation in Washington, D.C. He has been interviewed about his work by NPR, WBZ, WJR, CBS, ABC, and CNN.

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